Mathematical Model Analysis of Disease Spread Using Differential Equations
Keywords:
Mathematical Modeling; Differential Equations; Disease Spread; Epidemiology; SIR Model; Basic Reproduction Number.Abstract
This study aims to analyze the mathematical model of infectious disease spread using systems of differential equations. Mathematical epidemiology has become an important scientific approach in understanding disease transmission dynamics, predicting epidemic behavior, and evaluating public health intervention strategies. The study employs a mathematical analytical method using the Susceptible–Infected–Recovered (SIR) model to describe interactions among susceptible, infected, and recovered populations over time. The research process includes model formulation, equilibrium point analysis, basic reproduction number analysis, stability analysis, and numerical simulation of disease transmission dynamics. The mathematical model is represented through systems of ordinary differential equations involving transmission and recovery parameters to explain the progression of infectious diseases within a population. The results show that the transmission rate and recovery rate significantly influence epidemic behavior and disease spread intensity. The analysis of the basic reproduction number (R0)indicates that if R0>1, the disease spreads rapidly and may lead to an epidemic outbreak, whereas if R0<1, disease transmission gradually declines and eventually disappears. Stability analysis demonstrates that the disease-free equilibrium is stable when the reproduction number remains below one and unstable when the reproduction number exceeds one. Numerical simulations further illustrate epidemic phases consisting of initial growth, infection peak, and decline phases. The findings confirm that differential equations provide effective mathematical tools for understanding infectious disease dynamics and supporting evidence-based public health decision-making. However, the study also recognizes that simplified epidemiological models possess limitations because real-world disease transmission is influenced by demographic, environmental, behavioral, and social factors. Therefore, further research is recommended to develop more complex and realistic epidemiological models integrating additional variables and computational approaches.
References
Brauer, F., Castillo-Chavez, C., & Feng, Z. (2024). Mathematical Models in Epidemiology (3rd ed.). Springer.
Boyce, W. E., & DiPrima, R. C. (2021). Elementary Differential Equations and Boundary Value Problems (12th ed.). Wiley.
Giordano, F. R., Weir, M. D., & Fox, W. P. (2022). A First Course in Mathematical Modeling (6th ed.). Cengage Learning.
Hethcote, H. W. (2020). The mathematics of infectious diseases. SIAM Review, 42(4), 599–653.
Kermack, W. O., & McKendrick, A. G. (1927). A contribution to the mathematical theory of epidemics. Proceedings of the Royal Society A, 115(772), 700–721.
Martcheva, M. (2023). An Introduction to Mathematical Epidemiology (2nd ed.). Springer.
Murray, J. D. (2022). Mathematical Biology: I. An Introduction (4th ed.). Springer.
Perko, L. (2021). Differential Equations and Dynamical Systems (4th ed.). Springer.
Smith, H. L., & Waltman, P. (2020). The Theory of the Chemostat: Dynamics of Microbial Competition. Cambridge University Press.
Strogatz, S. H. (2021). Nonlinear Dynamics and Chaos: With Applications to Physics, Biology, Chemistry, and Engineering (3rd ed.). CRC Press.
World Health Organization. (2024). Global infectious disease surveillance and response report. Geneva: WHO Publications
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Christari Lois Palit, Gabriella Hillary Wenur, Mayawi, Jessica Debora Simbolon, Ratmila

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

